Usually means: Bitter fruit used in homeopathy.
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We found 3 dictionaries that define the word colocynthis:

General (2 matching dictionaries)
  1. colocynthis: Wiktionary
  2. colocynthis: Dictionary.com

Medicine (1 matching dictionary)
  1. Colocynthis: Medical dictionary

Definitions from Wiktionary (Colocynthis)

noun:  Obsolete form of colocynth. [A viny plant, Citrullus colocynthis, native to the Mediterranean Basin and Asia. It produces a lemon-sized, yellowish, green-mottled, spongy, and extremely bitter fruit.]

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