Usually means: Urge to urinate or defecate.
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We found 13 dictionaries that define the word call of nature:

General (10 matching dictionaries)
  1. call of nature, the call of nature: Merriam-Webster
  2. call of nature: Oxford Learner's Dictionaries
  3. call of nature: Collins English Dictionary
  4. call of nature: Cambridge Advanced Learner's Dictionary
  5. call of nature: Wiktionary
  6. call of nature: Infoplease Dictionary
  7. call of nature: Dictionary.com
  8. call of nature: TheFreeDictionary.com

Business (1 matching dictionary)
  1. call of nature: Legal dictionary

Computing (1 matching dictionary)
  1. call of nature: Encyclopedia

Miscellaneous (1 matching dictionary)
  1. call of nature: Idioms

Definitions from Wiktionary (call of nature)

noun:  (euphemistic) The bodily urge to urinate or defecate.

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