Usually means: Engaging someone in conversation forcefully.
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We found 10 dictionaries that define the word buttonholing:

General (9 matching dictionaries)
  1. buttonholing: Merriam-Webster
  2. buttonholing: Collins English Dictionary
  3. buttonholing: Vocabulary.com
  4. buttonholing: Wordnik
  5. buttonholing: Cambridge Advanced Learner's Dictionary
  6. buttonholing: Wiktionary
  7. buttonholing: Dictionary.com
  8. buttonholing: Cambridge Essential American English Dictionary
  9. buttonholing: TheFreeDictionary.com

Medicine (1 matching dictionary)
  1. buttonholing: Medical dictionary

(Note: See buttonhole as well.)

Definitions from Wiktionary (buttonholing)

noun:  The act of detaining someone in conversation against his or her will.

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