Usually means: Opening for excretion in humans.
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We found 10 dictionaries that define the word butthole:

General (7 matching dictionaries)
  1. butthole: Merriam-Webster
  2. butthole: American Heritage Dictionary of the English Language
  3. butthole: Wiktionary
  4. butthole: Dictionary.com
  5. Butthole: Wikipedia, the Free Encyclopedia
  6. butthole: TheFreeDictionary.com
  7. butthole: Longman Dictionary of Contemporary English

Computing (1 matching dictionary)
  1. butthole: Encyclopedia

Medicine (1 matching dictionary)
  1. butthole: Medical dictionary

Slang (1 matching dictionary)
  1. B.U.T.T.H.O.L.E: Urban Dictionary

Definitions from Wiktionary (butthole)

noun:  (Canada, US, mildly vulgar, slang) The anus.
noun:  (Canada, US, derogatory, euphemistic) An objectionable person; a bastard; a jerk.
noun:  (colloquial, derogatory) An unpleasant or undesirable place.

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