Usually means: Lacking sense, foolish, or stupid.
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We found 10 dictionaries that define the word buffle-headed:

General (10 matching dictionaries)
  1. buffle-headed: Merriam-Webster
  2. buffle-headed: Wordnik
  3. buffle-headed: Wiktionary
  4. Buffle-headed: Dictionary.com
  5. Buffle-headed: Online Plain Text English Dictionary
  6. buffle-headed: Webster's Revised Unabridged, 1913 Edition
  7. Buffle-headed: AllWords.com Multi-Lingual Dictionary
  8. buffle-headed: Webster's 1828 Dictionary
  9. buffle-headed: FreeDictionary.org
  10. Buffle-headed: TheFreeDictionary.com

Definitions from Wiktionary (buffle-headed)

adjective:  (obsolete) Having a large head, like a buffalo's.
adjective:  (obsolete) dull; stupid; blundering

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