Usually means: Boy isolated due to immunity.
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We found 5 dictionaries that define the word bubble boy:

General (3 matching dictionaries)
  1. bubble-boy: Wordnik
  2. Bubble Boy (film), Bubble Boy (musical), Bubble Boy, Bubble boy (disambiguation), Bubble boy, The Bubble Boy (Seinfeld), The Bubble Boy (Seinfeld episode): Wikipedia, the Free Encyclopedia
  3. bubble boy: Wiktionary

Art (1 matching dictionary)
  1. Bubble Boy: Seinfeld Dictionary

Slang (1 matching dictionary)
  1. Bubble Boy: Urban Dictionary

Definitions from Wiktionary (bubble boy)

noun:  A young man with severe combined immunodeficiency ("bubble boy disease") that requires him to live in a special sterile environment.

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