Usually means: Pause for biological necessities; restroom.
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We found 3 dictionaries that define the word biobreak:

General (1 matching dictionary)
  1. biobreak: Wiktionary

Computing (1 matching dictionary)
  1. biobreak: Netlingo

Slang (1 matching dictionary)
  1. biobreak: Urban Dictionary

Definitions from Wiktionary (Biobreak)

noun:  Alternative form of bio-break [(informal, euphemistic) A visit to a bathroom or restroom in order to relieve oneself.]

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