Usually means: Fleshy pad below the thumb.
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We found 3 dictionaries that define the word ball of the thumb:

General (3 matching dictionaries)
  1. the ball of the thumb: Oxford Learner's Dictionaries
  2. ball of the thumb: Wiktionary
  3. Ball of the thumb: Wikipedia, the Free Encyclopedia

Definitions from Wiktionary (ball of the thumb)

noun:  (anatomy, informal) The fleshy portion, opposite the nail, of the first segment (first phalange) of the human thumb.
noun:  (anatomy) The most fleshy portion of the palm of the human hand, located adjacent to the second joint of the thumb: the thenar eminence.

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