Usually means: Self-destruction of the spleen.
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We found 5 dictionaries that define the word autosplenectomy:

General (2 matching dictionaries)
  1. autosplenectomy: Wiktionary
  2. Autosplenectomy: Wikipedia, the Free Encyclopedia

Medicine (3 matching dictionaries)
  1. Dorland's Illustrated Medical Dictionary (No longer online)
  2. Hepatitis C Information Central (No longer online)
  3. autosplenectomy: Medical dictionary

Definitions from Wiktionary (autosplenectomy)

noun:  (medicine) Disease-induced progressive shrinkage and nonfunctionalisation of the spleen.

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