Usually means: Absence of a functioning spleen.
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We found 9 dictionaries that define the word asplenia:

General (3 matching dictionaries)
  1. asplenia: Wiktionary
  2. asplenia: Dictionary.com
  3. Asplenia: Wikipedia, the Free Encyclopedia

Medicine (6 matching dictionaries)
  1. asplenia: Merriam-Webster Medical Dictionary
  2. Dorland's Illustrated Medical Dictionary (No longer online)
  3. Asplenia: MedTerms.com Medical Dictionary
  4. online medical dictionary (No longer online)
  5. asplenia: Medical dictionary
  6. Asplenia: Drug Medical Dictionary

Definitions from Wiktionary (asplenia)

noun:  (biology, medicine) Absence of normal function of the spleen, from any cause:
noun:  (biology, medicine) Anatomical absence of the spleen (after splenectomy or congenitally).
noun:  (biology, medicine) Physiological absence of splenic function; either substantial or total splenic dysfunction; splenic nonfunction.

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