Definitions from Wiktionary ( )

▸ verb:  (intransitive) To writhe with agony; to suffer violent anguish.
▸ verb:  (intransitive) To struggle; to wrestle; to strive desperately, whether mentally or physically.
▸ verb:  (transitive) To cause agony or anguish in someone.
▸ verb:  (transitive, biochemistry, pharmacology) To act as an agonist upon; to combine with a receptor on a cell to produce a physiological reaction.

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