Sorry, no online dictionaries contain the exact phrase against grain.
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Reverse dictionary results:
1. contrary
2. contrary to popular belief
3. nonconformist
4. rebellious
5. iconoclastic
6. antithet
7. antithetical
8. adversative
9. self-contradictory
10. unintuitive
11. antipathetic
12. conflicting
13. polemical
14. adverse
15. antonymous
16. contradictional
17. contradictory
18. contrariety
19. illegal
20. oppugnant
21. transgressive
22. contrafactual
23. contrarian
24. contrariant
25. counterfactual
26. incompatible
27. opposite
28. skepticism
29. adversarial
30. antithetic
31. contradictive
32. contrarianism
33. gainsaying
34. genericness
35. hostile
36. ipsedixitism
37. maverick
38. nemesis
39. oppositional

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You can look up the words in the phrase individually using these links:   against ?   grain ?
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