Usually means: Historic highway across the U.S.
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We found 7 dictionaries that define the word Route 66:

General (3 matching dictionaries)
  1. route 66: Longman Dictionary of Contemporary English
  2. Route 66: Wiktionary

Art (1 matching dictionary)
  1. Encyclopedia of Television (No longer online)

Computing (1 matching dictionary)
  1. Route 66: Encyclopedia

Slang (1 matching dictionary)
  1. route 66: Urban Dictionary

Sports (1 matching dictionary)
  1. Hickok Sports Glossaries (No longer online)

Definitions from Wiktionary (Route 66)

noun:  A former United States highway that ran from Chicago to Los Angeles
noun:  The Capricorn Highway in Queensland, Australia

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