Might mean (unverified): Protein modification using polyethylene glycol.
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We found one dictionary that defines the word PEGyl:

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  1. PEGyl, pegyl: Wiktionary

Definitions from Wiktionary (Pegyl)

noun:  a functional group similar to the molecule polyethylene glycol (PEG)
noun:  Alternative form of PEGyl [a functional group similar to the molecule polyethylene glycol (PEG)]

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