Usually means: Philosophical system centered on Objectivism.
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We found 3 dictionaries that define the word OISM:

General (2 matching dictionaries)
  1. OISM: Wiktionary
  2. OISM: Dictionary.com

Miscellaneous (1 matching dictionary)
  1. OISM: Acronym Finder

Definitions from Wiktionary (OISM)

noun:  (sciences, medicine) Initialism of Oregon Institute of Science and Medicine.
noun:  (religion) Initialism of Orthodox Inter-Seminary Movement.

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