Usually means: Central U.S., culturally conservative region.
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We found 17 dictionaries that define the word Middle America:

General (15 matching dictionaries)
  1. middle america: Longman Dictionary of Contemporary English
  2. Middle America: Merriam-Webster
  3. Middle America: Oxford Learner's Dictionaries
  4. Middle America, Middle America: American Heritage Dictionary of the English Language
  5. Middle America: Collins English Dictionary
  6. middle-America: Wordnik
  7. Middle America: Wiktionary
  8. Middle America: The Wordsmyth English Dictionary-Thesaurus
  9. Middle America: Infoplease Dictionary
  10. Middle America: Dictionary.com
  11. Middle America (Americas), Middle America (US), Middle America (United States), Middle America (disambiguation), Middle America (song), Middle America: Wikipedia, the Free Encyclopedia
  12. Middle America: TheFreeDictionary.com
  13. Middle America: Merriam-Webster

Computing (1 matching dictionary)
  1. Middle America (U.S.), Middle America (disambiguation), Middle America (region), Middle America: Encyclopedia

Slang (1 matching dictionary)
  1. middle america: Urban Dictionary

(Note: See middle-american as well.)

Definitions from Wiktionary (Middle America)

noun:  (US) A portion of the United States comprising rural and suburban areas, and the mindsets of these areas.
noun:  (US) The American middle class.
noun:  (US) The Midwestern United States.
noun:  A geographical region comprising Mexico, Central America and the Caribbean

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