Usually means: Most significant bit in binary.
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We found 25 dictionaries that define the word MSB:

General (12 matching dictionaries)
  1. MSB: Oxford Learner's Dictionaries
  2. msb: Collins English Dictionary
  3. MSB: Vocabulary.com
  4. msb: Wordnik
  5. MSB: Wiktionary
  6. MSB: Dictionary.com
  7. MSB (album), MSB: Wikipedia, the Free Encyclopedia
  8. Msb: Rhymezone
  9. MSB: Stammtisch Beau Fleuve Acronyms
  10. msb: FreeDictionary.org
  11. msb: Mnemonic Dictionary
  12. msb: TheFreeDictionary.com

Business (1 matching dictionary)
  1. MSB: Financial dictionary

Computing (6 matching dictionaries)
  1. MSB: Free On-line Dictionary of Computing
  2. MSB: CCI Computer
  3. BABEL: Computer Oriented Abbreviations and Acronyms (No longer online)
  4. MSB: Unicode Glossary
  5. I T Glossary (No longer online)
  6. msb: Encyclopedia

Medicine (1 matching dictionary)
  1. online medical dictionary (No longer online)

Miscellaneous (2 matching dictionaries)
  1. MSB: Acronym Finder
  2. AbbreviationZ (No longer online)

Slang (1 matching dictionary)
  1. MSB: Urban Dictionary

Tech (2 matching dictionaries)
  1. Rane Professional Audio Reference (No longer online)
  2. Sweetwater Music (No longer online)

(Note: See msbs as well.)

Definitions from Wiktionary (MSB)

noun:  (computing) Initialism of most significant bit. [(computing) The bit that represents the largest fraction of a value, its position depending on the endianness of the system.]
noun:  (computing) Initialism of most significant byte. [(computer science) The byte of a multibyte number with the greatest importance: that is, the byte stored first on a big-endian system or last on a little-endian system.]
noun:  (telecommunications) Initialism of main switchboard.
noun:  (finance) Initialism of money services business.

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