Usually means: Interactive System Productivity Facility by IBM.
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We found 9 dictionaries that define the word ISPF:

General (3 matching dictionaries)
  1. ISPF: Wiktionary
  2. ISPF: Dictionary.com
  3. ISPF: Wikipedia, the Free Encyclopedia

Computing (3 matching dictionaries)
  1. ISPF: Free On-line Dictionary of Computing
  2. BABEL: Computer Oriented Abbreviations and Acronyms (No longer online)
  3. ISPF: Encyclopedia

Medicine (1 matching dictionary)
  1. online medical dictionary (No longer online)

Miscellaneous (2 matching dictionaries)
  1. ISPF: Acronym Finder
  2. AbbreviationZ (No longer online)

Definitions from Wiktionary (ISPF)

noun:  (computing) Initialism of Interactive System Productivity Facility; An IBM mainframe online application development system

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