Usually means: Detective, often associated with Sherlock.
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We found 21 dictionaries that define the word Holmes:

General (14 matching dictionaries)
  1. Holmes: Merriam-Webster
  2. Holmes: Collins English Dictionary
  3. Holmes: Vocabulary.com
  4. Holme's, Holmes, holmes: Wordnik
  5. Holmes: Wiktionary
  6. Holmes: Webster's New World College Dictionary, 4th Ed.
  7. Holmes: Infoplease Dictionary
  8. Holmes: Dictionary.com
  9. HOLMES, Holmes (TV series), Holmes (computer), Holmes (surname), Holmes: Wikipedia, the Free Encyclopedia
  10. Holmes: Rhymezone
  11. holmes: FreeDictionary.org
  12. holmes: Mnemonic Dictionary
  13. Holmes: TheFreeDictionary.com
  14. holmes: Wiktionary

Computing (1 matching dictionary)
  1. Holmes: Encyclopedia

Medicine (1 matching dictionary)
  1. Holmes: Merriam-Webster Medical Dictionary

Miscellaneous (3 matching dictionaries)
  1. baby names list (No longer online)
  2. HOLMES: Acronym Finder
  3. AbbreviationZ (No longer online)

Slang (2 matching dictionaries)
  1. holmes: Green’s Dictionary of Slang
  2. Holmes, Holmes: Urban Dictionary

(Note: See holmesing as well.)

Definitions from Wiktionary (Holmes)

noun:  A northern English surname from Middle English, variant of Holme.
noun:  a Scottish habitational surname from the place near Dundonald.
noun:  Sherlock Holmes, fictional detective.
noun:  by extension, someone acting like, or showing the ability of Sherlock Holmes.
noun:  (rare) A male given name transferred from the surname.
noun:  A hamlet in Tarleton parish, West Lancashire district, Lancashire, England (OS grid ref SD4319).
noun:  A suburb of Rotherham, South Yorkshire, England (OS grid ref SK4192).
noun:  A suburb of Darwin, Northern Territory, Australia.
noun:  A number of places in the United States:
noun:  An unincorporated community in Humboldt County, California.
noun:  An unincorporated community in Wright County, Iowa.
noun:  An unincorporated community in Adair County, Kentucky.
noun:  A township in Menominee County, Michigan.
noun:  A hamlet in Pawling, Dutchess County, New York.
noun:  A township in Crawford County, Ohio.
noun:  An unincorporated community in Delaware County, Pennsylvania.
noun:  (slang) An informal term of address, like man or dude.

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