Usually means: Life support system for spacecraft.
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We found 5 dictionaries that define the word ECLSS:

General (3 matching dictionaries)
  1. ECLSS: Wiktionary
  2. ECLSS: Dictionary.com
  3. ECLSS: Stammtisch Beau Fleuve Acronyms

Miscellaneous (2 matching dictionaries)
  1. ECLSS: Acronym Finder
  2. AbbreviationZ (No longer online)

Definitions from Wiktionary (ECLSS)

noun:  Initialism of environmental control and life support system.

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