Usually means: Excessive consumption of a substance.
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We found 7 dictionaries that define the word Drug overdose:

General (3 matching dictionaries)
  1. drug-overdose: Wordnik
  2. Drug overdose: Wikipedia, the Free Encyclopedia
  3. Drug overdose: TheFreeDictionary.com

Computing (1 matching dictionary)
  1. Drug overdose: Encyclopedia

Medicine (1 matching dictionary)
  1. drug overdose: Medical dictionary

Slang (2 matching dictionaries)
  1. drug overdose, Drug overdose: Urban Dictionary

Definitions from Wikipedia (Drug overdose)

noun:  A drug overdose (overdose or OD) is the ingestion or application of a drug or other substance in quantities much greater than are recommended.

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