Usually means: Dump them; move forward alone.
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We found 3 dictionaries that define the word DTMFA:

General (2 matching dictionaries)
  1. DTMFA: Wiktionary
  2. DTMFA: Dictionary.com

Miscellaneous (1 matching dictionary)
  1. DTMFA: Acronym Finder

Definitions from Wiktionary (DTMFA)

verb:  Initialism of dump the mother-fucker already, as advice to a partner in a relationship.

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