Sorry, no online dictionaries contain the exact phrase with great pain or difficulty.
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Reverse dictionary results:
1. ease
2. struggle
3. stiffness
4. hard
5. hell
6. difficulties
7. trouble
8. strain
9. hardship
10. struggling
11. toil
12. toiling
13. patient
14. stiff
15. distress
16. lame
17. mischief
18. alleviate
19. affliction
20. agonize
21. easily
22. ill
23. oll
24. scrape
25. lae
26. painful
27. reprieve
28. agony
29. severe
30. throe
31. torment
32. corner
33. smothering
34. flounder
35. kill
36. tormented
37. torture
38. indigestion
39. billow
40. choke

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You can look up the words in the phrase individually using these links:   with ?   great ?   pain ?   or ?   difficulty ?
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