Usually means: Active again after an illness.
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We found 9 dictionaries that define the word up and about:

General (7 matching dictionaries)
  1. up and about: Merriam-Webster
  2. up and about: Oxford Learner's Dictionaries
  3. up and about: Wiktionary
  4. up and about: Dictionary.com
  5. up and about: MyWord.info

Miscellaneous (1 matching dictionary)
  1. up and about: Idioms

Slang (1 matching dictionary)
  1. up and about: Urban Dictionary

Definitions from Wiktionary (up and about)

adjective:  (informal) Feeling well enough to be out of bed.

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