Sorry, no online dictionaries contain the exact phrase unsafe substance use.
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Reverse dictionary results:
1. addiction
 2. drug
3. preparation
4. abuse
5. culture
6. drugs
7. eating
8. poison
9. preserve
10. preserved
 11. preserves
12. preserving
13. wood
14. gum
15. consumerism
16. foodstuff
17. internet
18. spackle
19. consumer
20. consumption
 21. dependence
22. drinking
23. intake
24. modality
25. reagent
26. usage
27. vapor
28. vehicle
29. addictions
30. anesthetic
 31. controlled substance
32. food product
33. nebula
34. phosphorus
35. substances
36. consuming
37. dentifrice
38. encaustic
39. treatment
40. uptake

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You can look up the words in the phrase individually using these links:   unsafe ?   substance ?   use ?
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* useto search for words ending with use
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