Usually means: Extremely anxious, confused, or complicated.
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We found 6 dictionaries that define the word tied in knots:

General (2 matching dictionaries)
  1. tied in knots: TheFreeDictionary.com
  2. tied in knots: Wiktionary

Business (1 matching dictionary)
  1. tied in knots: Legal dictionary

Computing (1 matching dictionary)
  1. tied in knots: Encyclopedia

Medicine (1 matching dictionary)
  1. tied in knots: Medical dictionary

Miscellaneous (1 matching dictionary)
  1. tied in knots: Idioms

Definitions from Wiktionary (tied in knots)

adjective:  (idiomatic) In a state of confusion; in a difficult situation, in a bind.
adjective:  (idiomatic) Worried, anxious, upset.

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