Usually means: Confuse or complicate a situation.
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We found 6 dictionaries that define the word tie in knots:

General (2 matching dictionaries)
  1. tie in knots: TheFreeDictionary.com
  2. tie in knots: Wiktionary

Business (1 matching dictionary)
  1. tie in knots: Legal dictionary

Computing (1 matching dictionary)
  1. tie in knots: Encyclopedia

Medicine (1 matching dictionary)
  1. tie in knots: Medical dictionary

Miscellaneous (1 matching dictionary)
  1. tie in knots: Idioms

Definitions from Wiktionary (tie in knots)

verb:  (transitive, idiomatic) To put (someone) in a difficult situation.
verb:  (transitive, idiomatic) To make (someone) upset or anxious.

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