Usually means: Opportunity for personal gain, success.
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We found 7 dictionaries that define the word the main chance:

General (7 matching dictionaries)
  1. the main chance: Collins English Dictionary
  2. the main chance: Wordnik
  3. The main chance: Dictionary.com
  4. The Main Chance: Wikipedia, the Free Encyclopedia
  5. the main chance: FreeDictionary.org
  6. The main chance, The Main Chance: TheFreeDictionary.com

Definitions from Wikipedia (The Main Chance)

noun:  The Main Chance is a British television series first aired on ITV in four series between 1969 and 1975.
noun:  a 1964 British second feature film directed by John Knight and starring Grégoire Aslan, Edward De Souza and Tracy Reed.

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