Usually means: Assumes responsibility or confronts challenge.
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We found 6 dictionaries that define the word takes it on:

General (1 matching dictionary)
  1. takes it on: TheFreeDictionary.com

Business (2 matching dictionaries)
  1. takes it on: Legal dictionary
  2. takes it on: Financial dictionary

Computing (1 matching dictionary)
  1. takes it on: Encyclopedia

Medicine (1 matching dictionary)
  1. takes it on: Medical dictionary

Miscellaneous (1 matching dictionary)
  1. takes it on: Idioms


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