Usually means: Make feel intensely uncomfortable, irritated.
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We found 5 dictionaries that define the word set teeth on edge:

General (1 matching dictionary)
  1. set teeth on edge: TheFreeDictionary.com

Business (1 matching dictionary)
  1. set teeth on edge: Legal dictionary

Computing (1 matching dictionary)
  1. set teeth on edge: Encyclopedia

Medicine (1 matching dictionary)
  1. set teeth on edge: Medical dictionary

Miscellaneous (1 matching dictionary)
  1. set teeth on edge: Idioms


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