Usually means: Make a serious, disastrous mistake.
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We found 3 dictionaries that define the word screw the pooch:

General (3 matching dictionaries)
  1. screw the pooch: Merriam-Webster
  2. screw the pooch: Wiktionary
  3. Screw the pooch: Wikipedia, the Free Encyclopedia

Definitions from Wiktionary (screw the pooch)

verb:  (idiomatic) to make a large mistake, to fail in dramatic and ignominious fashion.

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