Sorry, no online dictionaries contain the exact phrase opposite of uptight.
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Reverse dictionary results:
1. relaxed
2. laid-back
3. easygoing
4. contentment
5. cool-headed
6. countenance
7. dolce far niente
8. ease
9. easefulness
10. easiness
11. easy
12. lax
13. leisure
14. lenient
15. stay
16. tranquilly
17. untroubledness
18. even-tempered
19. gently
20. laidback
21. laxism
22. lenience
23. noiselessness
24. safe
25. sangfroid
26. serenity
27. sober
28. sobriety
29. stresslessness
30. ataraxia
31. calm
32. calmness
33. clement
34. comfortably
35. cool
36. coolheaded
37. coy

You can look up the words in the phrase individually using these links:   opposite ?   of ?   uptight ?
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