Sorry, no online dictionaries contain the exact phrase opposite of trifling.
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Reverse dictionary results:
1. significant
 2. substantial
3. important
4. meaningful
5. weighty
6. consequential
7. considerable
8. importance
9. major
10. pivotal
 11. significative
12. vital
13. central
14. concerning
15. critical
16. decent
17. dominant
18. historic
19. instrumental
20. key
 21. material
22. mightly
23. pertinent
24. pitch
25. potency
26. potent
27. powerful
28. predominant
29. predominantly
30. preponderatingly
 31. relevant
32. strong point
33. superimportant
34. all-important
35. crucial
36. eminent

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