Sorry, no online dictionaries contain the exact phrase opposite of serendipity.
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Reverse dictionary results:
1. misfortune
2. disaster
3. unluckiness
4. unfortunate event
5. calamity
6. fatal
7. at-risk
8. bad news
9. deadly
10. deathful
11. deathly
12. disastrous
13. fatality
14. gunshy
15. illfare
16. killingly
17. lethal
18. lethality
19. life-threatening
20. visitation
21. ambsace
22. critically
23. desperate
24. devoted
25. doom
26. doomed
27. forlorn hope
28. jinx
29. misery
30. mortal
31. mortality
32. mortally
33. murderous
34. predicament
35. slight
36. tragic
37. weird
38. woe
39. bad luck

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You can look up the words in the phrase individually using these links:   opposite ?   of ?   serendipity ?
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