Sorry, no online dictionaries contain the exact phrase opposite of refine.
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Reverse dictionary results:
1. exalt
2. hone
3. finish
4. polish
5. civilize
6. concoct
7. concocted
8. develop
9. distill
10. file
11. fine
12. fines
13. furnace
14. grind
15. grinds
16. pure
17. school
18. smooth
19. spiritualize
20. sublime
21. train
22. ace
23. across
24. acute
25. against
26. anti
27. bang
28. bear
29. bell
30. bow
31. clash
32. come
33. dash
34. deadlock
35. decline
36. deep
37. diehard
38. eat
39. erase
40. erode

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You can look up the words in the phrase individually using these links:   opposite ?   of ?   refine ?
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