Sorry, no online dictionaries contain the exact phrase opposite of opposite of soothe.

Reverse dictionary results:
1. calm
2. ease
3. coy
4. lull
5. soften
6. quiet
7. salve
8. appease
9. console
10. curry
11. food
12. lave
13. qualify
14. qualifying
15. relieve
16. salving
17. smooth
18. smoothed
19. solace
20. stroke
21. stroked
22. sweeten
23. sweetened
24. angst
25. blow
26. contradict
27. contradicted
28. counteract
29. counterbalance
30. dweeb
31. ebb
32. ice
33. nerd
34. neutralize
35. neutralized
36. tail
37. tails
38. wane
39. stodgy
40. abate

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You can look up the words in the phrase individually using these links:   opposite ?   of ?   opposite ?   of ?   soothe ?
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