Sorry, no online dictionaries contain the exact phrase opposite of minuscule.
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Reverse dictionary results:
1. wee
2. imp
3. iota
4. nose
5. bit
6. majuscule
7. speck
8. small
9. trivial
10. atom
11. gnat
12. micro
13. whit
14. adult
15. ageratum
16. ally
17. angel
18. awkward
19. barb
20. brat
21. buttoned
22. cast
23. casted
24. flat
25. hope
26. iff
27. inch
28. janus
29. least
30. little
31. low
32. matte
33. much
34. odd
35. pff
36. piano
37. poor
38. short
39. shorts
40. spat

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You can look up the words in the phrase individually using these links:   opposite ?   of ?   minuscule ?
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*culeto search for words ending with cule
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