Sorry, no online dictionaries contain the exact phrase opposite of fruitless.
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Reverse dictionary results:
1. vanity
2. blank
3. blanking
4. blind alley
5. hollow
6. hollowing
7. idle
8. arid
9. bear
10. bell
11. cast
12. casted
13. diehard
14. economic
15. hybrid
16. ill
17. modest
18. neutralize
19. set
20. filled
21. fundus
22. helpful
23. meaningful
24. needed
25. occupied
26. aeneas silvius
27. aisha
28. amphoric
29. baffle
30. breach of the peace
31. break
32. budapest
33. cade
34. catiline
35. chaff
36. cheap shot
37. cheville
38. chin
39. chuff
40. chuffed

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You can look up the words in the phrase individually using these links:   opposite ?   of ?   fruitless ?
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*lessto search for words ending with less
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