Sorry, no online dictionaries contain the exact phrase most direct route.
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Reverse dictionary results:
1. beeline
 2. orthodromics
3. as the crow flies
4. devious
5. detour
6. shortcut
7. indirect
8. next
9. cut
10. near
 11. redirect
12. normal
13. extension
14. immediate
15. short
16. hit
17. jit
18. denotation
19. reference
20. nearest
 21. say
22. referenced
23. since
24. shortest
25. head
26. pitch
27. take
28. lead
29. one
30. around
 31. arterial
32. artery
33. last
34. line
35. channel
36. channelling
37. channels
38. circuitous
39. crosscut
40. flies

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You can look up the words in the phrase individually using these links:   most ?   direct ?   route ?
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