Sorry, no online dictionaries contain the exact phrase most astute.
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Reverse dictionary results:
1. perceptive
2. insightful
3. shrewd
4. clever
5. incisive
6. sententiously
7. insight
8. knowing
9. perspicaciously
10. perspicuously
11. poignant
12. revealingly
13. sagacious
14. sayette
15. sharpness
16. wit
17. wits
18. astute
19. clairvoyantly
20. cleverly
21. conceit
22. enlighteningly
23. euphorically
24. laconic
25. lucidly
26. penetrating
27. pithy
28. pontifically
29. prolixness
30. savviness
31. savvy
32. sententious
33. smart
34. acuteness
35. adroitness
36. brightness
37. brilliant
38. canny

You can look up the words in the phrase individually using these links:   most ?   astute ?
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