Usually means: Utilize circumstances to maximum advantage.
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We found 9 dictionaries that define the word make the best of:

General (7 matching dictionaries)
  1. make the best of: Merriam-Webster
  2. make the best of: Oxford Learner's Dictionaries
  3. make the best of: Collins English Dictionary
  4. make the best of: Cambridge Advanced Learner's Dictionary
  5. make the best of: Dictionary.com
  6. make the best of: TheFreeDictionary.com
  7. make the best of: Wiktionary

Business (1 matching dictionary)
  1. make the best of: Legal dictionary

Miscellaneous (1 matching dictionary)
  1. make the best of: Idioms

Definitions from Wiktionary (make the best of)

verb:  (idiomatic) to derive what limited advantage one can (from an unpleasant outcome or situation)
verb:  (idiomatic) to use (a resource) as well as possible; to be resourceful

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