Sorry, no online dictionaries contain the exact phrase make irrelevant.
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Reverse dictionary results:
1. disregard
2. ignore
3. dismiss
4. discount
5. amit
6. defeat
7. eschew
8. shun
9. spurn
10. delate
11. desert
12. dry
13. fordo
14. forsake
15. lose
16. lose sight of
17. omit
18. overlook
19. overlooker
20. aberr
21. abhor
22. avoid
23. break ranks
24. defect
25. defray
26. disappoint
27. dispose
28. draw a blank
29. evitate
30. evite
31. forbid
32. foredo
33. forget about
34. forspeak
35. leave out
36. oversee
37. oversight

You can look up the words in the phrase individually using these links:   make ?   irrelevant ?
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