Sorry, no online dictionaries contain the exact phrase make ineffective or powerless.
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Reverse dictionary results:
1. hamstring
 2. hamstrung
3. paralyze
4. paralyzed
5. paralyzing
6. idle
7. handcuff
8. sterilize
9. paralyse
10. neutralize
 11. deactivate
12. lame
13. neutralized
14. benumb
15. negate
16. annul
17. neutralise
18. cancel
19. disable
20. overpower
 21. stultify
22. vitiate
23. addle
24. break
25. cancelled
26. frustrate
27. jam
28. nullified
29. nullify
30. override
 31. puncture
32. strike down
33. void
34. addled
35. crush
36. break down
37. breakdown
38. counter
39. counteract
40. crack

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You can look up the words in the phrase individually using these links:   make ?   ineffective ?   or ?   powerless ?
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