Usually means: Large-scale, reliable enterprise computing systems.
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We found 5 dictionaries that define the word mainframe computers:

General (2 matching dictionaries)
  1. mainframe computers: Vocabulary.com
  2. Mainframe computers: Wikipedia, the Free Encyclopedia

Medicine (3 matching dictionaries)
  1. Medical Dictionary (No longer online)
  2. online medical dictionary (No longer online)
  3. Mainframe computers: Medical dictionary

(Note: See mainframe_computer as well.)

Definitions from Wikipedia (Mainframe computer)

noun:  A mainframe computer, informally called a mainframe or big iron, is a computer used primarily by large organizations for critical applications like bulk data processing for tasks such as censuses, industry and consumer statistics, enterprise resource planning, and large-scale transaction processing.
▸ Also see mainframe_computer


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