Sorry, no online dictionaries contain the exact phrase main thing that something does.

Reverse dictionary results:
1. rule
2. doer
3. absolute
4. outlier
5. exception
6. size
7. haecceity
8. quiddity
9. short
10. ripper
11. fear
12. appurtenance
13. much
14. predicate
15. contrast
16. corpus
17. idea
18. secret
19. cakewalk
20. preliminary
21. shorts
22. telltale
23. function
24. graft
25. source
26. body
27. leader
28. pivot
29. nucleus
30. difficulty
31. cap
32. venture
33. functionality
34. essence
35. event
36. shaker
37. most
38. tie-in
39. secretively
40. tang

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You can look up the words in the phrase individually using these links:   main ?   thing ?   that ?   something ?   does ?
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main*to search for words beginning with main, or
*doesto search for words ending with does
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