Usually means: Surprise or shock someone greatly.
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We found 8 dictionaries that define the word knock for a loop:

General (4 matching dictionaries)
  1. knock for a loop: Merriam-Webster
  2. knock for a loop: Wiktionary
  3. knock for a loop: Dictionary.com
  4. knock for a loop: TheFreeDictionary.com

Business (1 matching dictionary)
  1. knock for a loop: Legal dictionary

Computing (1 matching dictionary)
  1. knock for a loop: Encyclopedia

Medicine (1 matching dictionary)
  1. knock for a loop: Medical dictionary

Miscellaneous (1 matching dictionary)
  1. knock for a loop: Idioms

Definitions from Wiktionary (knock for a loop)

verb:  (transitive, idiomatic) To astonish; to stagger or overwhelm; to confuse or disorient.

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