Might mean (unverified): Situation is hopelessly, definitively over.
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We found 2 dictionaries that define the word goodnight Irene:

General (2 matching dictionaries)
  1. goodnight Irene: Wiktionary
  2. Goodnight Irene: Wikipedia, the Free Encyclopedia

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Definitions from Wiktionary (goodnight Irene)

▸ noun:  (idiomatic) An involuntary departure.

Similar:
adios, departure, sayonara, goodbye, leave, adieu, arrivederci, undern, overnight, depart, more...

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Similar:
adios, departure, sayonara, goodbye, leave, adieu, arrivederci, undern, overnight, depart, more...



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