Sorry, no online dictionaries contain the exact phrase given up on the world.
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Reverse dictionary results:
1. despairing
 2. hopeless
3. resigned
4. defeated
5. daunting
6. desinent
7. desolate
8. degenerous
9. demoralising
10. deprecatingly
 11. deprecatively
12. deprecatorily
13. depreciatively
14. desponding
15. dim
16. discouragement
17. disheartenment
18. dispond
19. forsaken
20. repellantly
 21. slight
22. underpropper
23. abjectness
24. at-risk
25. aversation
26. besetment
27. condescendence
28. defeasance
29. demoralizing
30. derelict
 31. dereliction
32. derogately
33. desolation
34. despair
35. desperation
36. disembarrassment
37. disregard
38. disrelish
39. duresse
40. exanimate

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You can look up the words in the phrase individually using these links:   given ?   up ?   on ?   the ?   world ?
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