Sorry, no online dictionaries contain the exact phrase estranged by comprehension.
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Reverse dictionary results:
1. lost
2. abstract
3. aloof
4. apercu
5. bill
6. blog
7. call
8. come
9. disconnect
10. distinct
11. fast
12. fasting
13. figure
14. gnomic
15. impersonal
16. jubilee
17. like
18. loose
19. needle
20. needling
21. notice
22. noticed
23. noticing
24. posting
25. publish
26. published
27. publishing
28. quarter
29. quarters
30. rate
31. section
32. sense datum
33. show
34. sign
35. slip
36. slipped
37. slipping
38. slips
39. squadron
40. thread

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You can look up the words in the phrase individually using these links:   estranged ?   by ?   comprehension ?
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Not helpful? You might try using the wildcards * and ? to find the word you're looking for. For example, use
estr*to search for words beginning with estr, or
*sionto search for words ending with sion
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