Usually means: Inflict significant damage or harm.
Definitions Related words Mentions
We found 10 dictionaries that define the word do a number on:

General (7 matching dictionaries)
  1. do a number on: Merriam-Webster
  2. do a number on: Oxford Learner's Dictionaries
  3. do a number on: Wiktionary
  4. do a number on, do a number on (someone): Dictionary.com
  5. do a number on: TheFreeDictionary.com

Business (1 matching dictionary)
  1. do a number on: Merriam-Webster Legal Dictionary

Miscellaneous (1 matching dictionary)
  1. do a number on: Idioms

Slang (1 matching dictionary)
  1. do a number on: Urban Dictionary

Definitions from Wiktionary (do a number on)

verb:  (informal) To damage; to treat harshly; to produce ill effects in.

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